Preimplantation genetic examination reduces miscarriage rate Study


The Japanese Society of Obstetrics and Gynecology (Japan) continued clinical research to determine whether the “pre-implantation test”, which examines all chromosomes in in vitro fertilized eggs and returns only those that are normal in the uterus of the mother, is effective. for the treatment of infertility. The maternity ward announced the interim results on the 23rd. The birth rate for all subjects was only 17%, but if fertilized eggs could be transplanted into the uterus, the miscarriage rate would decrease and the rate of pregnancy would decrease. pregnancy would tend to improve. “We will continue to carefully consider whether the test is beneficial,” the Nissan woman said.

Published at an online symposium. In medical facilities nationwide certified by Nissan women, I was in vitro fertilized but could not get pregnant more than once I had a miscarriage more than once One of the couples has a structural chromosomal abnormality – For the couple About 4,300 women in their 30s and 40s who were screened were analyzed. According to Nissan Women, the pregnancy rate for women who could transplant fertilized eggs into the uterus was 66%, and the miscarriage rate was 10%. The results of infertility treatment from medical facilities recorded by Nissan women in 2019 are pregnancy rate of 35% and miscarriage rate of 25%.

Although a simple comparison is not possible, the test was rated as “useful” as a fertility treatment only when the fertilized eggs could be transplanted. On the other hand, 60% of women could not find fertilized eggs without abnormal chromosome number and could not transplant them into the uterus. For this reason, the birth rate was 17% for all women tested. The birth rate for general in vitro fertilization without preimplantation inspection was approximately 20%, and no improvement was observed. The factors are believed to be that the rate of abnormalities in fertilized eggs increases with aging, and some of the fertilized eggs are damaged during the test.

Akira Kuwahara, director of Ladies Clinic Cosmos, which is in charge of the data, estimated that “60% could not be transplanted, but we were able to avoid a transplant which could not lead to pregnancy”, but the rate of overall birth rate has not been. to improve. “We have to check whether this will be beneficial for the couple,” he said. In the future, it is said that the analysis by age and by establishment will be favored. Pre-implantation tests usually look for an excess or a deficiency in the number of chromosomes, 23 versus 46. It is used abroad for the purpose of preventing miscarriages, and the Japanese Society of Reproductive Medicine says that it is “recommended” for women who have miscarried twice in a row when used for the purpose of preventing miscarriage.

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The Ministry of Health, Labor and Welfare is considering whether preimplantation examinations for the treatment of infertility in women who have had recurrent miscarriages should be included in the scope of public medical insurance to the Central Medical Council of Social Insurance, an advisory body to the Minister of Health, Labor and Welfare. On the other hand, Nissan women did not accept the guidelines because they fear it could lead to the elimination of fertilized eggs that may be born, such as Down syndrome, which has one more chromosome 21 and the syndrome. of Turner, who is one less sex. chromosome.

Symposium These ethical issues were also discussed at Mu. Koji Kugu, Director of Obstetrics and Gynecology Department at Sumida Hospital of Tokyo Bokuto Metropolitan Hospital, said, “It is a technology that helps prevent miscarriages and at the same time it helps prevent miscarriages. also leads to the elimination of disabled people. It is necessary to repeat the discussions. On the other hand, women with miscarriages and infertility complained, “I want you to be able to use tests to prevent miscarriages.”

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