Temporo-spatial pharmacometabolomics method to assess the microregional effect of OLZ on brain tissue

Announcement of the publication of a new article of Acta Pharmaceutica Sinica B. The brain is the most advanced organ with various complex structural and functional microregions. It is often difficult to understand what and where molecular events would occur for a given drug treatment in the brain.

The authors of this article propose a temporo-spatial pharmacometabolomics method based on ambient mass spectrometry imaging and applied it to evaluate the microregional effect of olanzapine (OLZ) on brain tissue and demonstrate its efficacy in characterize the microregional pharmacokinetics and pharmacodynamics of OLZ for a better understanding of the molecular mechanism of drugs acting on brain microregions.

The method accurately and simultaneously illustrated the level dynamics and microregional distribution of various substances, including exogenous drugs and their metabolites, as well as endogenous functional metabolites of complicated brain tissue. Targeted imaging analysis of the prototype drug and its metabolites showed the absorption, distribution, metabolism, and excretion characteristics of the drug itself. Additionally, endogenous functional metabolites were identified along with associated therapeutic and adverse drug effects, which may reflect the pharmacodynamic effect on the microregional brain.

This method is important for elucidating and understanding the molecular mechanism of central nervous system drugs at the temporal and spatial metabolic level of system biology.

Source:

Journal reference:

https://doi.org/10.1016/j.apsb.2022.03.018

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